Abnormalities in the alternative pathway of complement in children with hematopoietic stem cell transplant-associated thrombotic microangiopathy

Author:

Jodele Sonata1,Licht Christoph2,Goebel Jens3,Dixon Bradley P.3,Zhang Kejian4,Sivakumaran Theru A.4,Davies Stella M.1,Pluthero Fred G.2,Lu Lily2,Laskin Benjamin L.5

Affiliation:

1. Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH;

2. Division of Nephrology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada;

3. Division of Nephrology and Hypertension and

4. Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; and

5. Division of Nephrology, The Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA

Abstract

Key Points Genetic variations in the alternative pathway of complement may be associated with thrombotic microangiopathy in children receiving HSCT. These findings may guide the development of novel treatment interventions for this poorly understood transplant complication.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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