Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjögren’s syndrome

Author:

Nocturne Gaetane1,Boudaoud Saida1,Miceli-Richard Corinne12,Viengchareun Say3,Lazure Thierry4,Nititham Joanne5,Taylor Kimberly E.5,Ma Averil6,Busato Florence7,Melki Judith8,Lessard Christopher J.9,Sivils Kathy L.9,Dubost Jean-Jacques10,Hachulla Eric11,Gottenberg Jacques Eric12,Lombès Marc3,Tost Jorg7,Criswell Lindsey A.5,Mariette Xavier12

Affiliation:

1. Institut national de la santé et de la recherche médicale, Unité 1012, Université Paris-Sud, Le Kremlin Bicêtre, France;

2. Department of Rheumatology, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin Bicêtre, France;

3. Institut national de la santé et de la recherche médicale, Unité 693, Université Paris-Sud, Le Kremlin Bicêtre, France;

4. Department of Pathology, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin Bicêtre, France;

5. Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, CA;

6. Department of Medicine, University of California, San Francisco, CA;

7. Laboratory for Epigenetics, Commissariat à l'énergie atomique et aux énergies alternatives–Institut de Génomique, Centre National de Génotypage, Evry, France;

8. Unité mixte de recherche-788, Institut national de la santé et de la recherche médicale and Paris 11 University, Le Kremlin Bicêtre, France;

9. Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;

10. Department of Rheumatology, Centre hospitalier universitaire Gabriel Montpied, Clermont-Ferrand, France;

11. Department of Internal Medicine, Hôpital Claude Huriez, Université de Lille 2, Lille, France; and

12. Department of Rheumatology, Equipe d'accueil 4438, Strasbourg University Hospital, Hôpital Hautepierre, Strasbourg, France

Abstract

Key Points 77% of patients with primary Sjögren’s syndrome and mucosa-associated lymphoid tissue lymphoma have functional abnormalities of A20. A20 inactivation plays a key role in lymphomagenesis in the context of autoimmunity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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