CXCR7 participates in CXCL12-induced CD34+ cell cycling through β-arrestin–dependent Akt activation-Reference-Cited by-同舟云学术

CXCR7 participates in CXCL12-induced CD34+ cell cycling through β-arrestin–dependent Akt activation

Published:2014-01-09 Issue:2 Volume:123 Page:191-202
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Torossian Frédéric¹²,Anginot Adrienne¹²,Chabanon Aurélie¹²,Clay Denis¹²³,Guerton Bernadette¹²,Desterke Christophe¹²,Boutin Laetitia⁴,Marullo Stefano⁵,Scott Mark G. H.⁵,Lataillade Jean-Jacques¹⁴,Le Bousse-Kerdilès Marie-Caroline¹²⁶

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale U972, Villejuif, France;

2. Université Paris-Sud, Institut André Lwoff, Villejuif, France;

3. Institut Federatit de Recherche 89, Université Paris-Sud, Institut André Lwoff, Villejuif, France;

4. Centre de Transfusion Sanguine des Armées, Clamart, France;

5. Institut National de la Santé et de la Recherche Médicale U1016, Institut Cochin, Centre National de la Recherche Scientifique/Unité Mixte de Recherche 8104, Université Paris Descartes, Paris, France; and

6. Hôpital Paul Brousse, Villejuif, France

Abstract

Key Points CXCR7 is a key actor of the cell cycling and survival promoting effect of CXCL12 on primary human CD34+ HSPCs through Akt signaling. β-arrestins are signaling hubs downstream of CXCL12-activated receptors in primary human CD34+ HSPCs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/2/191/1376883/191.pdf

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