Loss of Asxl1 leads to myelodysplastic syndrome–like disease in mice-Reference-Cited by-同舟云学术

Loss of Asxl1 leads to myelodysplastic syndrome–like disease in mice

Published:2014-01-23 Issue:4 Volume:123 Page:541-553
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wang Jiapeng¹²,Li Zhaomin¹²,He Yongzheng¹²,Pan Feng¹²³,Chen Shi¹²,Rhodes Steven¹²,Nguyen Lihn¹²,Yuan Jin¹²,Jiang Li¹²,Yang Xianlin¹²,Weeks Ophelia³,Liu Ziyue⁴,Zhou Jiehao⁵,Ni Hongyu⁶,Cai Chen-Leng⁷,Xu Mingjiang¹²⁸,Yang Feng-Chun¹²⁹

Affiliation:

1. Department of Pediatrics, and

2. Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN;

3. Department of Biological Sciences, Florida International University, Miami, FL;

4. Department of Biostatistics, and

5. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN;

6. Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada;

7. Department of Developmental and Regenerative Biology, the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY; and

8. Department of Medical and Molecular Genetics, and

9. Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN

Abstract

Key Points Deletion/haploinsufficiency of Asxl1 causes MDS-like disease in mice. Asxl1 loss reduces the HSC pool and decreases HSC hematopoietic repopulating capacity in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/4/541/1378825/541.pdf

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