Rational design of small molecules targeting the C2 domain of coagulation factor VIII-Reference-Cited by-同舟云学术

Rational design of small molecules targeting the C2 domain of coagulation factor VIII

Published:2014-01-02 Issue:1 Volume:123 Page:113-120
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nicolaes Gerry A. F.¹,Kulharia Mahesh¹,Voorberg Jan²,Kaijen Paul H.²,Wroblewska Aleksandra²,Wielders Simone¹,Schrijver Roy¹,Sperandio Olivier³,Villoutreix Bruno O.³

Affiliation:

1. Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands;

2. Department of Plasma Proteins, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands; and

3. Institut National de la Santé et de la Recherche Médicale U973, University Paris Diderot, Paris, France

Abstract

Key Points Novel small molecules have been identified that specifically target FVIII. These small molecules are able to reduce in vitro thrombin formation in full blood.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/1/113/1373834/113.pdf

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4. The role of phospholipids and factor Va in the prothrombinase complex.;Rosing;J Biol Chem,1980

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