The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease-Reference-Cited by-同舟云学术

The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease

Published:2013-12-12 Issue:25 Volume:122 Page:4119-4128
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

He Shan¹,Xie Fang¹,Liu Yongnian¹,Tong Qing¹,Mochizuki Kazuhiro¹,Lapinski Philip E.²,Mani Ram-Shankar³,Reddy Pavan¹,Mochizuki Izumi¹,Chinnaiyan Arul M.³,Mineishi Shin⁴,King Philip D.²,Zhang Yi¹

Affiliation:

1. Department of Internal Medicine,

2. Department of Microbiology and Immunology, and

3. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI; and

4. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

Abstract

Key Points Ezh2 is specifically required to induce effector cells producing IFN-γ and expansion of T cells late upon alloantigen activation. Genetic inactivation of Ezh2 function reduces GVHD but preserves antitumor effects in mice after allogeneic BMT.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/25/4119/1371988/4119.pdf

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