Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression-Reference-Cited by-同舟云学术

Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression

Published:2013-11-28 Issue:23 Volume:122 Page:3767-3777
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Laperrousaz Bastien¹²³⁴⁵,Jeanpierre Sandrine¹²³⁴⁵,Sagorny Karen¹²³⁴⁵,Voeltzel Thibault¹²³⁴⁵,Ramas Sophie¹²³⁴⁵,Kaniewski Bastien¹²³⁴⁵,Ffrench Martine⁶,Salesse Stéphanie⁷,Nicolini Franck E.⁶⁸,Maguer-Satta Véronique¹²³⁴⁵

Affiliation:

1. Centre National de la Recherche Scientifique Unité Mixte de Recherche UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France;

2. Institut National de la Santé et de la Recherche Médicale U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France;

3. Université de Lyon, Lyon, France;

4. Department of Immunity, Virus, and Microenvironment, Lyon, France;

5. Université de Lyon 1, Lyon, France;

6. Hospices Civils de Lyon, Hematology Department, Centre Hospitalier Lyon Sud, Pierre Bénite, France;

7. Centre National de la Recherche Scientifique Unité Mixte de Recherche 6237, Unité de Formation et de Recherche Sciences Exactes et Naturelles, Reims, France; and

8. France Intergroupe de la Leucémie Myéloïde Chronique, Poitiers, France

Abstract

Key Points In CML, early alterations of the BMP pathway are involved in the survival of hypersensitive LSCs and the expansion of myeloid progenitors. The leukemic niche provides higher concentrations of BMP2 and BMP4 that fuel a permanent and autonomous pool of leukemic progenitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/23/3767/1464290/3767.pdf

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