Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

Author:

Saha Asim1,Aoyama Kazutoshi1,Taylor Patricia A.1,Koehn Brent H.1,Veenstra Rachelle G.1,Panoskaltsis-Mortari Angela1,Munn David H.2,Murphy William J.3,Azuma Miyuki4,Yagita Hideo5,Fife Brian T.6,Sayegh Mohammed H.7,Najafian Nader7,Socie Gerard8,Ahmed Rafi9,Freeman Gordon J.10,Sharpe Arlene H.1112,Blazar Bruce R.1

Affiliation:

1. Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN;

2. Department of Pediatrics, School of Medicine, Medical College of Georgia, Augusta, GA;

3. Department of Dermatology, University of California, Davis, CA;

4. Department of Molecular Immunology, Tokyo Medical and Dental University, Tokyo, Japan;

5. Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;

6. Department of Medicine and Center for Immunology, University of Minnesota, Minneapolis, MN;

7. Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Boston, MA;

8. Service d'Hématologie-Greffe, Hôpital Saint-Louis, Assistance Publique-Hopitaux de Paris, Université Paris VII Denis-Diderot, and Unité Institut National de la Santé et de la Recherche Médicale U940, Paris, France;

9. Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA;

10. Department of Medical Oncology, Dana-Farber Cancer Institute, and

11. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA; and

12. Department of Pathology, Brigham and Women’s Hospital, Boston, MA

Abstract

Key Points PD-L1 and PD-L2 expression were upregulated during GVHD, whereas PD-1/PD-L1 was more critical than PD-1/PD-L2 in downregulating GVHD. Our data provide new insight into the differential roles of host PD-L1 and PD-L2 and associated mechanisms in controlling GVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3