PLCG1 mutations in cutaneous T-cell lymphomas

Author:

Vaqué José P.1,Gómez-López Gonzalo2,Monsálvez Verónica3,Varela Ignacio4,Martínez Nerea1,Pérez Cristina1,Domínguez Orlando2,Graña Osvaldo2,Rodríguez-Peralto José L.3,Rodríguez-Pinilla Socorro M.5,González-Vela Carmen6,Rubio-Camarillo Miriam2,Martín-Sánchez Esperanza12,Pisano David G.2,Papadavid Evangelia7,Papadaki Theodora8,Requena Luis5,García-Marco José A.910,Méndez Miriam910,Provencio Mariano910,Hospital Mercedes9,Suárez-Massa Dolores9,Postigo Concepción3,San Segundo David16,López-Hoyos Marcos16,Ortiz-Romero Pablo L.3,Piris Miguel A.16,Sánchez-Beato Margarita10

Affiliation:

1. Instituto Formación Investigación Hospital Universitario Marqués de Valdecilla, Santander, Spain;

2. Spanish National Cancer Research Center, Madrid, Spain;

3. Instituto I+12, Hospital Universitario 12 de Octubre, Madrid, Spain;

4. Instituto Biomedicina y Biotecnología de Cantabria, Santander, Spain;

5. Fundación Jiménez Diaz, Madrid, Spain;

6. Hospital Universitario Marqués de Valdecilla, Santander, Spain;

7. A Syggros Hospital for Skin Diseases, University of Athens Medical School, Athens, Greece;

8. Evangelismos Hospital, Athens, Greece;

9. Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain; and

10. Instituto Investigación Sanitaria Puerta de Hierro, Madrid, Spain

Abstract

Key Points Activating mutations in PLCG1 are a frequent finding in tumoral CTCL samples. This raises the possibility of targeted therapies against PLCG1 signaling pathway, using calcineurin inhibitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3