PLCG1 mutations in cutaneous T-cell lymphomas-Reference-Cited by-同舟云学术

PLCG1 mutations in cutaneous T-cell lymphomas

Published:2014-03-27 Issue:13 Volume:123 Page:2034-2043
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vaqué José P.¹,Gómez-López Gonzalo²,Monsálvez Verónica³,Varela Ignacio⁴,Martínez Nerea¹,Pérez Cristina¹,Domínguez Orlando²,Graña Osvaldo²,Rodríguez-Peralto José L.³,Rodríguez-Pinilla Socorro M.⁵,González-Vela Carmen⁶,Rubio-Camarillo Miriam²,Martín-Sánchez Esperanza¹²,Pisano David G.²,Papadavid Evangelia⁷,Papadaki Theodora⁸,Requena Luis⁵,García-Marco José A.⁹¹⁰,Méndez Miriam⁹¹⁰,Provencio Mariano⁹¹⁰,Hospital Mercedes⁹,Suárez-Massa Dolores⁹,Postigo Concepción³,San Segundo David¹⁶,López-Hoyos Marcos¹⁶,Ortiz-Romero Pablo L.³,Piris Miguel A.¹⁶,Sánchez-Beato Margarita¹⁰

Affiliation:

1. Instituto Formación Investigación Hospital Universitario Marqués de Valdecilla, Santander, Spain;

2. Spanish National Cancer Research Center, Madrid, Spain;

3. Instituto I+12, Hospital Universitario 12 de Octubre, Madrid, Spain;

4. Instituto Biomedicina y Biotecnología de Cantabria, Santander, Spain;

5. Fundación Jiménez Diaz, Madrid, Spain;

6. Hospital Universitario Marqués de Valdecilla, Santander, Spain;

7. A Syggros Hospital for Skin Diseases, University of Athens Medical School, Athens, Greece;

8. Evangelismos Hospital, Athens, Greece;

9. Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain; and

10. Instituto Investigación Sanitaria Puerta de Hierro, Madrid, Spain

Abstract

Key Points Activating mutations in PLCG1 are a frequent finding in tumoral CTCL samples. This raises the possibility of targeted therapies against PLCG1 signaling pathway, using calcineurin inhibitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/13/2034/1374690/2034.pdf

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