Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes-Reference-Cited by-同舟云学术

Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes

Published:2013-12-12 Issue:25 Volume:122 Page:4077-4085
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Clemente Michael J.¹,Przychodzen Bartlomiej¹,Jerez Andres¹,Dienes Brittney E.¹,Afable Manuel G.¹,Husseinzadeh Holleh¹,Rajala Hanna L. M.²,Wlodarski Marcin W.³,Mustjoki Satu²,Maciejewski Jaroslaw P.¹

Affiliation:

1. Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;

2. Hematology Research Unit, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; and

3. Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany

Abstract

Key PointsT-cell repertoire deep sequencing clearly identifies the nucleotide and amino acid sequence of the immunodominant clone in T-LGL leukemia patients. Deep-sequencing results suggest that CD8+ T-LGL leukemia is characterized by specific CDR3 clonotypes that are private to the disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/25/4077/1371851/4077.pdf

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