Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type–specific hypomethylated regions-Reference-Cited by-同舟云学术

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type–specific hypomethylated regions

Published:2013-12-12 Issue:25 Volume:122 Page:e52-e60
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zilbauer Matthias¹²³,Rayner Tim F.¹²,Clark Christine⁴,Coffey Alison J.⁴,Joyce Chris J.⁴,Palta Priit⁴,Palotie Aarno⁴⁵⁶⁷,Lyons Paul A.¹²,Smith Kenneth G. C.¹²

Affiliation:

1. Department of Medicine and

2. Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;

3. Department of Paediatric Gastroenterology, Addenbrooke's Hospital, Cambridge, United Kingdom;

4. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom;

5. Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland;

6. Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA; and

7. Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

Abstract

Key Points We provide a functional DNA methylation map of human leukocyte subsets and identify cell-type–specific regulatory HMRs. We illustrate use of this data by demonstrating a potential link between gene polymorphisms, DNA methylation, and immune-mediated disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/25/e52/1371931/e52.pdf

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