Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype-Reference-Cited by-同舟云学术

Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype

Published:2014-02-20 Issue:8 Volume:123 Page:1250-1260
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tyagi Tarun¹,Ahmad Shadab²,Gupta Neha¹,Sahu Anita¹,Ahmad Yasmin¹,Nair Velu³,Chatterjee Tathagat⁴,Bajaj Nitin⁵,Sengupta Shantanu²,Ganju Lilly¹,Singh Shashi Bala¹,Ashraf Mohammad Z.¹

Affiliation:

1. Defense Institute of Physiology & Allied Sciences, Timarpur, Delhi, India;

2. Council of Scientific and Industrial Research–Institute of Genomics and Integrative Biology, New Delhi, India;

3. Armed Forces Medical College, Pune, India;

4. Army Hospital (Research & Referral), New Delhi, India; and

5. Western Command Hospital Chandimandir, Chandigarh, India

Abstract

Key Points Hypoxia induces altered platelet proteome/reactivity, which correlates with a prothrombotic phenotype. CAPNS1-dependent calpain activity in platelet activation cascade is associated with hypoxia-induced thrombogenesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/8/1250/1379441/1250.pdf

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