Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality-Reference-Cited by-同舟云学术

Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality

Published:2013-11-21 Issue:22 Volume:122 Page:3651-3658
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Pidala Joseph¹,Wang Tao²,Haagenson Michael³,Spellman Stephen R.³,Askar Medhat⁴,Battiwalla Minoo⁵,Baxter-Lowe Lee Ann⁶,Bitan Menachem⁷,Fernandez-Viña Marcelo⁸,Gandhi Manish⁹,Jakubowski Ann A.¹⁰,Maiers Martin¹¹,Marino Susana R.¹²,Marsh Steven G. E.¹³,Oudshoorn Machteld¹⁴,Palmer Jeanne¹⁵,Prasad Vinod K.¹⁶,Reddy Vijay¹⁷,Ringden Olle¹⁸,Saber Wael²,Santarone Stella¹⁹,Schultz Kirk R.²⁰,Setterholm Michelle¹¹,Trachtenberg Elizabeth²¹,Turner E. Victoria²²,Woolfrey Ann E.²³,Lee Stephanie J.²³,Anasetti Claudio¹

Affiliation:

1. H. Lee Moffitt Cancer Center, Tampa, FL;

2. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

3. Center for International Blood and Marrow Transplant Research, Minneapolis, MN;

4. Transplantation Center, Cleveland Clinic, Cleveland, OH;

5. National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD;

6. Immunogentics and Transplantation Laboratory, University of California San Francisco Medical Center; San Francisco, CA;

7. Department of Pediatric Hematology/Oncology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel;

8. Pathology/Blood Center, Stanford University Hospital and Clinics, Stanford, CA;

9. Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN;

10. Hematologic Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY;

11. National Marrow Donor Program, Minneapolis, MN;

12. Department of Pathology, University of Chicago, IL;

13. Anthony Nolan Research Institute and University College London, United Kingdom;

14. Europdonor Foundation, Leiden University Medical Center, Leiden, The Netherlands;

15. Division of Hematology and Oncology, Children's Hospital of Wisconsin, Milwaukee, WI;

16. Division of Blood and Marrow Transplantation, Duke University Medical Center, Durham, NC;

17. Pediatrics, University of Florida, Gainesville, FL;

18. Department of Laboratory Medicine, Karolinska University Hospital, Stockholm, Sweden;

19. Department of Hematology, Ospedale Civile BMT Center, Pescara, Italy;

20. Pediatric Hematology/Oncology/BMT, British Columbia's Children's Hospital, UBC, Vancouver, BC, Canada;

21. Center for Applied Genomics, Children's Hospital & Research Center Oakland, CA;

22. HLA Laboratory, Pathology, St Jude Children's Research Hospital, Memphis, TN; and

23. Fred Hutchinson Cancer Research Center, Seattle, WA

Abstract

Key Points Amino acid substitution at peptide-binding residues of the HLA class I molecule is associated with graft-versus-host disease and mortality. Avoidance of donor-recipient combinations that result in amino acid substitution at peptide-binding residues may improve transplant outcomes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/22/3651/1372037/3651.pdf

Reference37 articles.

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4. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors.;Morishima;Blood,2002

5. Association of HLA-C disparity with graft failure after marrow transplantation from unrelated donors.;Petersdorf;Blood,1997

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