Functional distance between recipient and donor HLA-DPB1 determines nonpermissive mismatches in unrelated HCT-Reference-Cited by-同舟云学术

Functional distance between recipient and donor HLA-DPB1 determines nonpermissive mismatches in unrelated HCT

Published:2016-07-07 Issue:1 Volume:128 Page:120-129
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Crivello Pietro¹^ORCID,Heinold Andreas²,Rebmann Vera²,Ottinger Hellmut D.³,Horn Peter A.²⁴,Beelen Dietrich W.³^ORCID,Fleischhauer Katharina¹⁴^ORCID

Affiliation:

1. Institute for Experimental Cellular Therapy,

2. Institute for Transfusion Medicine, and

3. Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany; and

4. German Cancer Consortium, Heidelberg, Germany

Abstract

Key Points Nonpermissive mismatches associated with survival after HCT reflect FD between recipient-donor HLA-DPB1. FD within HLA-DPB1 is determined by the combined impact of nonconservative peptide-binding AA substitutions.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/1/120/1395334/120.pdf

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