BCR-ABL1 mutation ≠ ponatinib resistance
Author:
Affiliation:
1. UNIVERSITY OF TURIN
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/127/6/666/1394066/666.pdf
Reference10 articles.
1. Compound mutations in BCR-ABL1 are not major drivers of primary or secondary resistance to ponatinib in CP-CML patients.;Deininger;Blood,2016
2. Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia.;O’Hare;Blood,2007
3. Ponatinib in refractory Philadelphia chromosome-positive leukemias.;Cortes;N Engl J Med,2012
4. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias.;Cortes;N Engl J Med,2013
5. Many BCR-ABL1 compound mutations reported in chronic myeloid leukemia patients may actually be artifacts due to PCR-mediated recombination.;Parker;Blood,2014
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1. Isoalantolactone mediates the degradation of BCR-ABL protein in imatinib-resistant CML cells by down-regulating survivin;Cell Cycle;2023-05-18
2. Assessing Measurable Residual Disease in Chronic Myeloid Leukemia. BCR-ABL1 IS in the Avant-Garde of Molecular Hematology;Frontiers in Oncology;2019-09-23
3. Molecular biology as a tool for the treatment of cancer;Clinical and Experimental Medicine;2018-07-13
4. Chk1 inhibitors overcome imatinib resistance in chronic myeloid leukemia cells;Leukemia Research;2018-01
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