Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations

Author:

Louissaint Abner12,Schafernak Kristian T.3,Geyer Julia T.4,Kovach Alexandra E.5,Ghandi Mahmoud6,Gratzinger Dita7,Roth Christine G.8,Paxton Christian N.9,Kim Sunhee2,Namgyal Chungdak10,Morin Ryan11,Morgan Elizabeth A.10,Neuberg Donna S.12,South Sarah T.13,Harris Marian H.5,Hasserjian Robert P.1,Hochberg Ephraim P.14,Garraway Levi A.26,Harris Nancy Lee1,Weinstock David M.26

Affiliation:

1. Department of Pathology, Massachusetts General Hospital, Boston, MA;

2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

3. Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL;

4. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/New York–Presbyterian Hospital, New York, NY;

5. Department of Pathology, Boston Children's Hospital, Boston, MA;

6. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA;

7. Department of Pathology, Stanford University School of Medicine, Stanford, CA;

8. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA;

9. ARUP Institute for Clinical and Experimental Pathology, Department of Pathology, University of Utah, Salt Lake City, UT;

10. Department of Pathology, Brigham & Women's Hospital, Boston, MA;

11. Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada;

12. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA;

13. ARUP Laboratories, Department of Pathology, University of Utah, Salt Lake City, UT; and

14. Department of Medicine, Massachusetts General Hospital, Boston, MA

Abstract

Key Points PTNFL is a biologically distinct indolent lymphoma characterized by common MEK/ERK pathway mutations. The biology of PTNFL is not defined by age, as the mutational profile is similar in pediatric and adult cases.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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