Phase 1 studies of central memory–derived CD19 CAR T–cell therapy following autologous HSCT in patients with B-cell NHL-Reference-Cited by-同舟云学术

Phase 1 studies of central memory–derived CD19 CAR T–cell therapy following autologous HSCT in patients with B-cell NHL

Published:2016-06-16 Issue:24 Volume:127 Page:2980-2990
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wang Xiuli¹,Popplewell Leslie L.¹,Wagner Jamie R.¹,Naranjo Araceli¹,Blanchard M. Suzette²,Mott Michelle R.³,Norris Adam P.³,Wong ChingLam W.¹,Urak Ryan Z.¹,Chang Wen-Chung¹,Khaled Samer K.¹,Siddiqi Tanya¹,Budde Lihua E.¹,Xu Jingying¹,Chang Brenda¹,Gidwaney Nikita⁴,Thomas Sandra H.¹,Cooper Laurence J. N.⁵,Riddell Stanley R.⁶,Brown Christine E.¹,Jensen Michael C.⁷,Forman Stephen J.¹

Affiliation:

1. Department of Hematology and Hematopoietic Cell Transplantation,

2. Department of Information Sciences,

3. Clinical Trials Unit, and

4. Department of Radiology, City of Hope, Duarte, CA;

5. Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX;

6. Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA; and

7. Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute and School of Medicine, Seattle, WA

Abstract

Key Points TCM-derived CD19 CAR T–cell therapy is safe for treatment of poor-risk NHL patients undergoing autologous HSCT. Addition of a CD28 costimulatory domain to the CAR, plus changes to T-cell product manufacturing, resulted in improved T-cell expansion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/24/2980/1394503/2980.pdf

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