c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish

Author:

Jin Hao1,Huang Zhibin2,Chi Yali2,Wu Mei2,Zhou Riyang2,Zhao Lingfeng2,Xu Jin1,Zhen Fenghua1,Lan Yahui1,Li Li3,Zhang Wenqing2,Wen Zilong1,Zhang Yiyue2

Affiliation:

1. State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, People’s Republic of China;

2. Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People’s Republic of China; and

3. The Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, State Key Laboratory Breeding Base of Eco-Environments and Bio-Resources of the Three Gorges Area, School of Life Science, Southwest University, Chongqing, People’s Republic of China

Abstract

Key Points c-Myb is essential for neutrophil terminal differentiation by targeting granule gene expression. c-Myb and Cebp1 act cooperatively to regulate neutrophil maturation in zebrafish.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference67 articles.

1. Neutrophil function: from mechanisms to disease.;Amulic;Annu Rev Immunol,2012

2. Neutrophils, from marrow to microbes.;Borregaard;Immunity,2010

3. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils.;Galli;Nat Immunol,2011

4. Neutrophils in the activation and regulation of innate and adaptive immunity.;Mantovani;Nat Rev Immunol,2011

5. The role of transcription factors in the guidance of granulopoiesis.;Fiedler;Am J Blood Res,2012

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