Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury–associated coagulopathy in mice-Reference-Cited by-同舟云学术

Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury–associated coagulopathy in mice

Published:2016-06-02 Issue:22 Volume:127 Page:2763-2772
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhao Zilong¹²,Wang Min³,Tian Ye¹,Hilton Tristan²,Salsbery Breia²,Zhou Eric Z.²,Wu Xiaoping²,Thiagarajan Perumal⁴⁵,Boilard Eric⁶,Li Min³,Zhang Jianning¹,Dong Jing-fei²⁷

Affiliation:

1. Department of Neurosurgery, Tianjin Institute of Neurology, Tianjin Medical University General Hospital, Tianjin, China;

2. BloodWorks Northwest Research Institute, Seattle, WA;

3. Institute of Pathology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China;

4. Department of Pathology and

5. Department of Medicine, Baylor College of Medicine, Houston, TX;

6. Centre de Recherche du Centre Hospitalier Universitaire de Québec, Department of Infectious Diseases and Immunity, Université Laval and Faculté de Médecine de l’Université Laval, Quebec City, QC, Canada; and

7. Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, WA

Abstract

Key Points Mitochondria were released from traumatically injured brain into systemic circulation and exposed CL on their surface. CL-exposed mitochondria are highly procoagulant and induced traumatic brain injury–associated coagulopathy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/22/2763/1393521/2763.pdf

Reference47 articles.

1. Blunt brain injury activates the coagulation process.;Hulka;Arch Surg,1996

2. Experience with antithrombin concentrates in neurotrauma patients.;Hoots;Semin Thromb Hemost,1997

3. Severity of head injury is associated with increased risk of coagulopathy in combat casualties.;Cap;J Trauma,2011

4. Validating the incidence of coagulopathy and disseminated intravascular coagulation in patients with traumatic brain injury--analysis of 242 cases.;Sun;Br J Neurosurg,2011

5. Coagulopathy in severe traumatic brain injury: a prospective study.;Talving;J Trauma,2009

Cited by 75 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mitochondrial Extracellular Vesicles: A Promising Avenue for Diagnosing and Treating Lung Diseases;ACS Nano;2024-09-03

2. Relationship between coagulopathy score and ICU mortality: Analysis of the MIMIC-IV database;Heliyon;2024-07

3. EASIX is an effective marker in predicting mortality of traumatic brain injury patients;European Journal of Medical Research;2024-05-29

4. Extracellular vesicles in disorders of hemostasis following traumatic brain injury;Frontiers in Neurology;2024-05-09

5. When Our Best Friend Becomes Our Worst Enemy: The Mitochondrion in Trauma, Surgery, and Critical Illness;Journal of Intensive Care Medicine;2024-03-20