Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis-Reference-Cited by-同舟云学术

Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis

Published:2016-03-31 Issue:13 Volume:127 Page:1666-1675
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Das Rupali¹,Guan Peng²,Sprague Leslee²,Verbist Katherine³,Tedrick Paige³,An Qi Angel⁴,Cheng Cheng⁴,Kurachi Makoto⁵,Levine Ross⁶,Wherry E. John⁵,Canna Scott W.⁷,Behrens Edward M.⁷,Nichols Kim E.³

Affiliation:

1. Department of Physiology, Michigan State University, East Lansing, MI;

2. Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA;

3. Department of Oncology and

4. Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN;

5. Department of Microbiology, Institute for Immunology, University of Pennsylvania, Philadelphia, PA;

6. Department of Oncology, Memorial Sloan Kettering Cancer Center, New York, NY; and

7. Division of Rheumatology, The Children’s Hospital of Philadelphia, Philadelphia, PA

Abstract

Key Points Ruxolitinib treatment lessens immunopathology and prolongs survival in murine models of hemophagocytic lymphohistiocytosis. In vivo exposure to ruxolitinib limits CD8+ T-cell expansion and proinflammatory cytokine production.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/13/1666/1392477/1666.pdf

Reference41 articles.

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3. Hemophagocytic syndromes--an update.;Janka;Blood Rev,2014

4. Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol.;Trottestam;Blood,2011

5. Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab.;Marsh;Pediatr Blood Cancer,2013

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