Critical requirement of VEGF-C in transition to fetal erythropoiesis

Author:

Fang Shentong1,Nurmi Harri1,Heinolainen Krista1,Chen Shuo1,Salminen Essi1,Saharinen Pipsa1,Mikkola Hanna K. A.2,Alitalo Kari1

Affiliation:

1. Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; and

2. Department of Molecular, Cell and Developmental Biology, Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA

Abstract

Key Points Vegfc is essential for mobilization, maturation, and enucleation of primitive erythroblasts. Vegfc deletion compromises liver colonization by erythro-myeloid progenitors and subsequent macrophage/erythroid expansion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference55 articles.

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3. Development of hematopoietic stem cell activity in the mouse embryo.;Müller;Immunity,1994

4. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse.;Palis;Development,1999

5. The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis.;Tober;Blood,2007

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