Affiliation:
1. CEA, I2BM, Service de Recherches en Hemato-Immunologie, Paris, France
Abstract
Abstract
Human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex (MHC) class I molecule that functions as an immunomodulatory molecule capable of protecting fetal tissues from the maternal immune system. The relevance of HLA-G in other contexts was investigated soon afterward. Numerous studies have sought (and some have shown) the relevance of HLA-G in pathologic conditions, such as transplantation, autoimmunity, and cancer and hematologic malignancies. One of the main goals of the current research on HLA-G is now to use it in the clinic, either for diagnosis or as a therapeutic tool/target. For this, precise knowledge on the nature and functions of HLA-G is critical. We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant.
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Reference94 articles.
1. Evidence for a novel HLA antigen found on human extravillous trophoblast and a choriocarcinoma cell line.;Ellis;Immunology,1986
2. A human major histocompatibility complex class I gene that encodes a protein with shortened cytoplasmic segment.;Geraghty;Proc Natl Acad Sci U S A,1987
3. Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA Class I molecule.;Ellis;J Immunol,1990
4. A class I antigen, HLA-G, expressed in human trophoblasts.;Kovats;Science,1990
5. HLA-G in the human thymus: a subpopulation of medullary epithelial but not CD83(+) dendritic cells expresses HLA-G as a membrane-bound and soluble protein.;Mallet;Int Immunol,1999
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