Single- vs double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndrome

Author:

Michel Gérard12,Galambrun Claire1,Sirvent Anne3,Pochon Cecile4,Bruno Benedicte5,Jubert Charlotte6,Loundou Anderson2,Yakoub-Agha Ibrahim7,Milpied Noel8,Lutz Patrick9,Marie-Cardine Aude10,Gandemer Virginie11,Blaise Didier12,Michallet Mauricette13,Rialland Fanny14,Renard Cecile15,Oudin Claire12,Esmiol Sophie1,Seux Mylene16,Baumstarck Karine2,Mohty Mohamad17,Rocha Vanderson18,Dalle Jean-Hugues19

Affiliation:

1. Department of Pediatric Hematology-Oncology, Assistance Publique–Hôpitaux de Marseille, La Timone Hospital, Aix-Marseille University, Marseille, France;

2. Department of Public Health, Laboratoire de Santé Publique (EA 3279) Research Unit, Marseille University Hospital, Aix-Marseille University, Marseille, France;

3. Department of Pediatric Hematology-Oncology, Montpellier University Hospital, Montpellier, France;

4. Department of Pediatric Hematology-Oncology, Nancy University Hospital, Nancy, France;

5. Department of Pediatric Hematology, Jeanne de Flandre Hospital, Lille Nord de France University, Lille, France;

6. Department of Pediatric Hematology-Oncology, Bordeaux University Hospital, Bordeaux, France;

7. Department of Hematology, Huriez Hospital, Lille Nord de France University, Lille, France;

8. Department of Hematology, Haut-Leveque Hospital, Bordeaux University Hospital, Pessac, France;

9. Department of Pediatric Hematology-Oncology, Strasbourg University Hospital, Strasbourg, France;

10. Department of Pediatric Hematology-Oncology, Rouen University Hospital, Rouen, France;

11. Department of Pediatric Hematology-Oncology, Rennes University Hospital, Rennes, France;

12. Department of Hematology-Oncology, Transplant and Cellular Therapy Unit, Paoli-Calmettes Institute, Centre de Recherche en Cancérologie de Marseille and Aix-Marseille University, Marseille, France;

13. Department of Hematology, Edouard Herriot Hospital, Lyon University Hospital, Lyon, France;

14. Department of Pediatric Hematology-Oncology, Nantes University Hospital, Nantes, France;

15. Institute of Pediatric Hematology-Oncology, Lyon University Hospital, Lyon, France;

16. Clinical Research and Innovation Direction, Assistance Publique–Hôpitaux de Marseille, Marseille, France;

17. Department of Hematology, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital Saint-Antoine, Université Pierre and Marie Curie, Inserm Unité 938, Paris, France;

18. Eurocord, Hôpital Saint Louis AP-HP, University Paris VII, Paris, France; and

19. Department of Pediatric Hematology, AP-HP, Robert Debré Hospital, Paris Diderot University, Paris, France

Abstract

Key Points A double-unit strategy does not decrease transplantation failure risk when a single unit of cord blood with adequate cell dose is available. Alloreactivity may be enhanced by double-unit cord blood transplantation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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