Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Author:

Bolzoni Marina1ORCID,Chiu Martina2ORCID,Accardi Fabrizio13,Vescovini Rosanna1,Airoldi Irma4,Storti Paola15,Todoerti Katia6,Agnelli Luca7,Missale Gabriele8,Andreoli Roberta9,Bianchi Massimiliano G.29ORCID,Allegri Manfredi2,Barilli Amelia2,Nicolini Francesco10,Cavalli Albertina8,Costa Federica1,Marchica Valentina15,Toscani Denise1,Mancini Cristina11,Martella Eugenia11,Dall’Asta Valeria2,Donofrio Gaetano12,Aversa Franco13,Bussolati Ovidio2ORCID,Giuliani Nicola135ORCID

Affiliation:

1. Myeloma Unit, Department of Clinical and Experimental Medicine, and

2. Unit of General Pathology, Department of Biomedical, Biotechnological and Translational Sciences, University of Parma, Parma, Italy;

3. Hematology and BMT Center, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy;

4. Laboratorio di Oncologia, Istituto Giannina Gaslini, Genoa, Italy;

5. CoreLab, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy;

6. Laboratory of Pre-clinical and Translational Research, Istituto di Ricovero e Cura a Carattere Scientifico, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy;

7. Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy;

8. Infectious Disease Unit and Hepatology Unit, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy;

9. Unit of Occupational Medicine, Department of Clinical and Experimental Medicine, and

10. Cardiac Surgery Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy;

11. U.O. di Anatomia Patologica, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy; and

12. Department of Medical-Veterinary Science, University of Parma, Parma, Italy

Abstract

Key Points Myeloma cells produce ammonium in the presence of glutamine, showing high glutaminase and low glutamine synthetase expression. Myeloma cells show high expression of glutamine transporters and inhibition of ASCT2 transporter hinders myeloma growth.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference60 articles.

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