CBFβ-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice-Reference-Cited by-同舟云学术

CBFβ-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice

Published:2016-09-15 Issue:11 Volume:128 Page:1503-1515
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cai Qi¹,Jeannet Robin¹,Hua Wei-Kai¹,Cook Guerry J.¹,Zhang Bin¹,Qi Jing¹,Liu Hongjun¹,Li Ling¹,Chen Ching-Cheng¹,Marcucci Guido¹,Kuo Ya-Huei¹^ORCID

Affiliation:

1. Division of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA

Abstract

Key Points CM impairs erythroid lineage specification and differentiation from Pre-Meg/E progenitors. CM creates abnormal preleukemic Pre-Meg/E progenitors predisposed to leukemia initiation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/11/1503/1395375/1503.pdf

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