Risk stratification of chromosomal abnormalities in chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy

Author:

Wang Wei1,Cortes Jorge E.2,Tang Guilin1,Khoury Joseph D.1,Wang Sa1,Bueso-Ramos Carlos E.1,DiGiuseppe Joseph A.3,Chen Zi1,Kantarjian Hagop M.2,Medeiros L. Jeffrey1,Hu Shimin1

Affiliation:

1. Department of Hematopathology and

2. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX; and

3. Department of Pathology, Hartford Hospital, Hartford, CT

Abstract

Key Points Based on their impact on treatment and survival, ACAs in CML were stratified into good and poor prognostic groups. ACAs in the good prognostic group showed no adverse impact on survival when they emerged from chronic phase or at the initial CML diagnosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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