Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy-Reference-Cited by-同舟云学术

Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy

Published:2016-07-21 Issue:3 Volume:128 Page:395-404
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Herling Carmen Diana¹,Klaumünzer Marion¹,Rocha Cristiano Krings¹,Altmüller Janine²,Thiele Holger²,Bahlo Jasmin¹,Kluth Sandra¹,Crispatzu Giuliano¹³,Herling Marco¹³,Schiller Joanna¹,Engelke Anja¹,Tausch Eugen⁴,Döhner Hartmut⁴,Fischer Kirsten¹,Goede Valentin¹,Nürnberg Peter²³⁵,Reinhardt Hans Christian¹³,Stilgenbauer Stephan⁴,Hallek Michael¹³,Kreuzer Karl-Anton¹

Affiliation:

1. Department of Internal Medicine I, Center of Integrated Oncology Cologne-Bonn,

2. Cologne Center for Genomics, and

3. Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany;

4. Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany; and

5. Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

Abstract

Key Points First prospective, controlled study to identify complex karyotypes as an independent prognostic factor of survival in CLL. First study to show that mutations in KRAS or POT1 impact treatment response and survival after chemoimmunotherapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/3/395/1359337/395.pdf

Reference52 articles.

1. Genomic aberrations and survival in chronic lymphocytic leukemia.;Döhner;N Engl J Med,2000

2. Mutations driving CLL and their evolution in progression and relapse.;Landau;Nature,2015

3. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.;Puente;Nature,2011

4. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia.;Quesada;Nat Genet,2011

5. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia.;Wang;N Engl J Med,2011

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