p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix-Reference-Cited by-同舟云学术

p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix

Published:2016-04-21 Issue:16 Volume:127 Page:1967-1975
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Reddy Pavankumar N. G.¹^ORCID,Radu Maria²,Xu Ke¹,Wood Jenna¹,Harris Chad E.¹,Chernoff Jonathan²,Williams David A.¹³

Affiliation:

1. Division of Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

2. Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA; and

3. Harvard Stem Cell Institute, Harvard University, Boston, MA

Abstract

Key Points Pak2 kinase activity and β-Pix interaction regulate HSPC directional migration, actin remodeling, homing, and engraftment. Pak2 regulates homing of HSPCs to the bone marrow via CDC42 activation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/16/1967/1392662/1967.pdf

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4. Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.;Gu;Science,2003

5. Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment.;Wang;Blood,2006

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