Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia-Reference-Cited by-同舟云学术

Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia

Published:2016-11-10 Issue:19 Volume:128 Page:2319-2326
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Speedy Helen E.¹,Kinnersley Ben¹,Chubb Daniel¹,Broderick Peter¹,Law Philip J.¹,Litchfield Kevin¹,Jayne Sandrine²,Dyer Martin J. S.²,Dearden Claire³,Follows George A.⁴,Catovsky Daniel⁵,Houlston Richard S.¹⁵

Affiliation:

1. Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom;

2. Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, United Kingdom;

3. Department of Haemato-Oncology, The Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom;

4. Department of Haematology, Cambridge University Hospitals National Health Service Foundation Trust, Addenbrooke’s Hospital, Cambridge, United Kingdom; and

5. Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom

Abstract

Key Points Germ line loss-of-function mutations in shelterin genes occur in a subset of families with CLL. Telomere dysregulation is further implicated in CLL predisposition.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/19/2319/1396343/2319.pdf

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