An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation-Reference-Cited by-同舟云学术

An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation

Published:2016-06-16 Issue:24 Volume:127 Page:2991-3003
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Avellino Roberto¹,Havermans Marije¹,Erpelinck Claudia¹,Sanders Mathijs A.¹,Hoogenboezem Remco¹,van de Werken Harmen J. G.²³⁴^ORCID,Rombouts Elwin¹,van Lom Kirsten¹,van Strien Paulina M. H.¹,Gebhard Claudia⁵⁶,Rehli Michael⁵⁶,Pimanda John⁷,Beck Dominik⁷,Erkeland Stefan¹⁸,Kuiken Thijs⁹,de Looper Hans¹,Gröschel Stefan¹¹⁰,Touw Ivo¹,Bindels Eric¹,Delwel Ruud¹

Affiliation:

1. Department of Hematology,

2. Cancer Computational Biology Center,

3. Department of Cell Biology, and

4. Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands;

5. Department of Internal Medicine III and

6. Regensburg Centre for Interventional Immunology, University Hospital Regensburg, Regensburg, Germany;

7. Prince of Wales Clinical Schools and Lowy Cancer Research Centre, The University of New South Wales, Sydney, NSW, Australia;

8. Department of Immunology and

9. Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands; and

10. Department of Translational Oncology, National Center for Tumor Diseases, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany

Abstract

Key Points The CEBPA locus harbors 14 enhancers of which distinct combinations are active in different CEBPA-expressing tissues. A +42-kb enhancer is required for myeloid-lineage priming to drive adequate CEBPA expression levels necessary for neutrophilic maturation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/24/2991/1394093/2991.pdf

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