Randomized phase 2 study: elotuzumab plus bortezomib/dexamethasone vs bortezomib/dexamethasone for relapsed/refractory MM

Author:

Jakubowiak Andrzej1ORCID,Offidani Massimo2,Pégourie Brigitte3,De La Rubia Javier4,Garderet Laurent5,Laribi Kamel6,Bosi Alberto7,Marasca Roberto8,Laubach Jacob9,Mohrbacher Ann10,Carella Angelo Michele11,Singhal Anil K.12,Tsao L. Claire12,Lynch Mark13,Bleickardt Eric13,Jou Ying-Ming14,Robbins Michael15,Palumbo Antonio16

Affiliation:

1. Myeloma Program, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL;

2. Clinica di Ematologia, Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona, Ancona, Italy;

3. Centre Hospitalier Universitaire de Grenoble–Hôpital Albert Michallon, Grenoble, France;

4. Hospital Universitario Doctor Peset and Universidad Católica “San Vicente Mártir,” Valencia, Spain;

5. Service d'hématologie, Hôpital Saint Antoine, Paris, France;

6. Department of Hematology, Centre Hospitalier, Le Mans, France;

7. Department of Hematology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy;

8. Department of Hematology, Azienda Ospedaliera Universitaria–Policlinico di Modena, Modena, Italy;

9. Department of Hematology/Oncology, Dana-Farber Cancer Institute, Boston, MA;

10. Division of Hematology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA;

11. Hematology Unit, Istituto di Ricovero e Cura a Carattere Scientifico San Martino–Istituto Scientifico Tumori, Genoa, Italy;

12. Statistics, AbbVie Biotherapeutics Inc, Redwood City, CA;

13. Oncology Clinical Development, Bristol-Myers Squibb, Wallingford, CT;

14. Global Biometric Sciences, Bristol-Myers Squibb, Hopewell, NJ;

15. Exploratory Clinical and Translational Research–Oncology, Bristol-Myers Squibb, Princeton, NJ; and

16. Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy

Abstract

Key Points Elotuzumab, an immunostimulatory antibody, prolongs PFS with no added clinical toxicity when combined with Bd vs Bd alone in RRMM. Based on results from this phase 2 study, further investigation of elotuzumab with a proteasome inhibitor in RRMM is warranted.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference25 articles.

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2. Future of cancer incidence in the United States: burdens upon an aging, changing nation.;Smith;J Clin Oncol,2009

3. National Comprehensive Cancer Network (NCCN) NCCN Clinical Practice Guidelines for Treatment of Cancer by Site: Multiple Myeloma. Version 2.2016, September 22, 2015. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed December 15, 2015

4. Immuno-oncology combinations: a review of clinical experience and future prospects.;Antonia;Clin Cancer Res,2014

5. What have we learned from cancer immunotherapy in the last 3 years?;Ascierto;J Transl Med,2014

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