Dimethyl fumarate restores apoptosis sensitivity and inhibits tumor growth and metastasis in CTCL by targeting NF-κB-Reference-Cited by-同舟云学术

Dimethyl fumarate restores apoptosis sensitivity and inhibits tumor growth and metastasis in CTCL by targeting NF-κB

Published:2016-08-11 Issue:6 Volume:128 Page:805-815
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nicolay Jan P.¹²,Müller-Decker Karin³,Schroeder Anne²,Brechmann Markus²,Möbs Markus⁴⁵,Géraud Cyrill¹,Assaf Chalid⁴⁶,Goerdt Sergij¹,Krammer Peter H.²,Gülow Karsten²

Affiliation:

1. Department of Dermatology, Venereology and Allergy, University Medical Center Mannheim, Ruprecht-Karls University of Heidelberg, Mannheim, Germany;

2. Division of Immunogenetics, and

3. Core Facility Tumor Models, German Cancer Research Center, Heidelberg, Germany;

4. Department of Dermatology, Venereology and Allergy, and

5. Institute of Pathology, University Medical Center Charité, Berlin, Germany; and

6. Department of Dermatology, Venereology and Allergy, HELIOS Klinikum, Krefeld, Germany

Abstract

Key Points DMF induces specific cell death in CTCL cells and inhibits CTCL tumor growth and metastasis in vivo via inhibition of NF-κB. DMF therefore represents a promising, nontoxic novel therapeutic approach to treating CTCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/6/805/1397976/805.pdf

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