Chimeric antigen receptor T cells targeting Fc μ receptor selectively eliminate CLL cells while sparing healthy B cells

Author:

Faitschuk Elena12,Hombach Andreas A.12,Frenzel Lukas P.23,Wendtner Clemens-Martin24,Abken Hinrich12

Affiliation:

1. Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany;

2. Department I Internal Medicine, University Hospital Cologne, Cologne, Germany;

3. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany; and

4. Klinikum Schwabing, Munich, Germany

Abstract

Key Points FcμR is a more selective target for the CAR T-cell therapy of CLL compared with currently used targets, including CD19.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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