PET-CT for staging and early response: results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study

Author:

Barrington Sally F.1,Kirkwood Amy A.2,Franceschetto Antonella3,Fulham Michael J.45,Roberts Thomas H.2,Almquist Helén6,Brun Eva7,Hjorthaug Karin8,Viney Zaid N.9,Pike Lucy C.1,Federico Massimo10,Luminari Stefano10,Radford John11,Trotman Judith512,Fosså Alexander13,Berkahn Leanne14,Molin Daniel15,D’Amore Francesco16,Sinclair Donald A.1,Smith Paul2,O’Doherty Michael J.1,Stevens Lindsey2,Johnson Peter W.17

Affiliation:

1. PET Imaging Centre, Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital, London, United Kingdom;

2. Cancer Research UK and UCL Cancer Trials Centre, London, United Kingdom;

3. Department of Nuclear Medicine, University of Modena and Reggio Emilia, Modena, Italy;

4. Department of Molecular Imaging (PET-CT), Royal Prince Alfred Hospital, Sydney, Australia;

5. Sydney Medical School, University of Sydney, Sydney, Australia;

6. Department of Medical Imaging and Physiology and

7. Department of Oncology and Radiation Physics, Skane University Hospital, Lund University, Lund, Sweden;

8. Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark;

9. Department of Radiology, Guy's and St. Thomas' National Health Service (NHS) Foundation Trust, London, United Kingdom;

10. Oncology Unit, Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy;

11. The University of Manchester and the Christie NHS Foundation Trust, Manchester, United Kingdom;

12. Concord, Repatriation General Hospital, Sydney, Australia;

13. Department of Oncology, Norwegian Radium Hospital, Oslo, Norway;

14. Haematology, Auckland City Hospital, Auckland, New Zealand;

15. Department of Genetics and Pathology, Experimental and Clinical Oncology, Uppsala University, Uppsala, Sweden;

16. Haematology, Aarhus University, Aarhus, Denmark; and

17. Cancer Research UK Centre, University of Southampton, Southampton, United Kingdom

Abstract

Key Points PET-CT is the modern standard for staging Hodgkin lymphoma and can replace contrast enhanced CT in the vast majority of cases. Agreement between expert and local readers is sufficient for the Deauville criteria to assess response in clinical trials and the community.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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