Differential role of Id1 in MLL-AF9–driven leukemia based on cell of origin-Reference-Cited by-同舟云学术

Differential role of Id1 in MLL-AF9–driven leukemia based on cell of origin

Published:2016-05-12 Issue:19 Volume:127 Page:2322-2326
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Man Na¹,Sun Xiao-Jian¹²,Tan Yurong¹,García-Cao Marta³,Liu Fan¹⁴,Cheng Guoyan¹,Hatlen Megan³,Xu Haiming³,Shah Ronit¹,Chastain Nolan¹,Liu Na⁵,Huang Gang⁶,Zhou Yuan⁷,Sheng Mengyao⁷,Song Junhong⁸,Yang Feng-Chun¹⁴,Benezra Robert³,Nimer Stephen D.¹⁴⁹,Wang Lan¹²⁴⁵

Affiliation:

1. Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL;

2. State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;

3. Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY;

4. Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL;

5. Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/School of Medicine, Shanghai Jiao Tong University, Shanghai, China;

6. Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH;

7. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Tianjin, China;

8. Pediatric Hematology and Oncology, Shanghai Children’s Medical Center, Shanghai, China; and

9. Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL

Abstract

Key Points Loss of Id1 delays leukemogenesis in fetal MLL-AF9 leukemia model, but accelerates leukemogenesis in postnatal MLL-AF9 leukemia model. Deletion of Cdkn1a (p21) rescues the loss of Id1 in both MLL-AF9 mouse models.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/19/2322/1393253/2322.pdf

Reference24 articles.

1. The ID proteins: master regulators of cancer stem cells and tumour aggressiveness.;Lasorella;Nat Rev Cancer,2014

2. Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells.;Jankovic;Proc Natl Acad Sci USA,2007

3. Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance.;Perry;Blood,2007

4. Id1 restrains p21 expression to control endothelial progenitor cell formation.;Ciarrocchi;PLoS One,2007

5. ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21.;O’Brien;Cancer Cell,2012

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