Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained-Reference-Cited by-同舟云学术

Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained

Published:2014-08-14 Issue:7 Volume:124 Page:1099-1109
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vandenberg Cassandra J.¹²,Waring Paul³,Strasser Andreas¹²,Cory Suzanne¹²

Affiliation:

1. The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia; and

2. Departments of Medical Biology and

3. Pathology, University of Melbourne, VIC, Australia

Abstract

Key Points Loss of Bim accelerated the development and increased the incidence of plasmacytomas in Eμ-v-abl transgenic mice. As in multiple myeloma, elevated expression of myc and cyclin D genes was common and p53 deregulation was rare.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/7/1099/1383357/1099.pdf

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3. Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.;Bernard;EMBO J,1983

4. An Eμ-v-abl transgene elicits plasmacytomas in concert with an activated myc gene.;Rosenbaum;EMBO J,1990

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