Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race-Reference-Cited by-同舟云学术

Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race

Published:2014-11-27 Issue:23 Volume:124 Page:3450-3458
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Edelstein Leonard C.¹,Simon Lukas M.²,Lindsay Cory R.¹,Kong Xianguo¹,Teruel-Montoya Raúl¹,Tourdot Benjamin E.¹,Chen Edward S.²,Ma Lin¹,Coughlin Shaun³,Nieman Marvin⁴,Holinstat Michael¹,Shaw Chad A.²⁵,Bray Paul F.¹

Affiliation:

1. Cardeza Foundation for Hematologic Research, Sidney Kimmel Medical College, Philadelphia, PA;

2. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX;

3. Cardiovascular Research Institute, University of California, San Francisco, CA;

4. Department of Pharmacology, Case Western Reserve University, Cleveland, OH; and

5. Department of Statistics, Rice University, Houston, TX

Abstract

Key Points White individuals have a high frequency of the common PAR4 gene (F2RL3) variant Ala120; blacks have a high frequency of Thr120. PAR4 Thr120 induces greater signaling and is associated with greater platelet aggregation and reduced inhibition by a PAR4 antagonist.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/23/3450/1381618/3450.pdf

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