JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2-Reference-Cited by-同舟云学术

JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2

Published:2014-11-06 Issue:19 Volume:124 Page:2996-3006
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kagoya Yuki¹,Yoshimi Akihide¹,Tsuruta-Kishino Takako¹,Arai Shunya¹,Satoh Takashi²³,Akira Shizuo²³,Kurokawa Mineo¹

Affiliation:

1. Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; and

2. Laboratory of Host Defense, World Premier International Research Center Initiative, Immunology Frontier Research Center, and

3. Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

Abstract

Key Points JAK2V617F+ MPN clones induce paracrine DNA damage into coexisting normal clones through secretion of lipocalin-2. Lipocalin-2 suppresses normal hematopoiesis via p53 pathway activation and gives relative growth advantage to MPN clones.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/19/2996/1381193/2996.pdf

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