The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia

Published:2015-02-19 Issue:8 Volume:125 Page:1282-1291
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Schinnerl Dagmar¹,Fortschegger Klaus¹,Kauer Maximilian¹,Marchante João R. M.²,Kofler Reinhard³,Den Boer Monique L.²,Strehl Sabine¹

Affiliation:

1. CCRI, Children’s Cancer Research Institute, St. Anna Kinderkrebsforschung e.V., Vienna, Austria;

2. Department of Pediatric Oncology and Hematology, Erasmus MC/Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands; and

3. Division of Molecular Pathophysiology, Tyrolean Cancer Research Institute and Biocenter, Innsbruck Medical University, Innsbruck, Austria

Abstract

Key Points PAX5-JAK2 is the first nuclear DNA-binding JAK2 fusion protein with kinase activity. JAK2 inhibitors block the kinase activity of PAX5-JAK2.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/8/1282/1388171/1282.pdf

Reference76 articles.

1. Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study.;Coyaud;Blood,2010

2. Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia.;Nebral;Leukemia,2009

3. Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.;Roberts;Cancer Cell,2012

4. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.;Roberts;N Engl J Med,2014

5. Pax5: a master regulator of B cell development and leukemogenesis.;Medvedovic;Adv Immunol,2011

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