MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis

Author:

Rondelli Damiano12ORCID,Goldberg Judith D.23ORCID,Isola Luis24,Price Leah S.23,Shore Tsiporah B.25,Boyer Michael6ORCID,Bacigalupo Andrea27,Rambaldi Alessandro28,Scarano Marco29,Klisovic Rebecca B.210,Gupta Vikas211,Andreasson Bjorn212,Mascarenhas John24ORCID,Wetzler Meir213,Vannucchi Alessandro M.214,Prchal Josef T.26,Najfeld Vesna24,Orazi Attilio25,Weinberg Rona S.215,Miller Crystal24,Barosi Giovanni216,Silverman Lewis R.24,Prosperini Giuseppe29,Marchioli Roberto29,Hoffman Ronald24

Affiliation:

1. University of Illinois Hospital & Health Sciences System and University of Illinois Cancer Center, Chicago, IL;

2. Myeloproliferative Disorders Research Consortium, Mount Sinai School of Medicine, New York, NY;

3. New York University School of Medicine, New York, NY;

4. Mount Sinai Medical Center, New York, NY;

5. Weill Cornell Medical College, New York, NY;

6. University of Utah School of Medicine, Salt Lake City, UT;

7. Ospedale San Martino, Genoa, Italy;

8. Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy;

9. Foundation Mario Negri Sud, S. Maria Imbaro, Italy;

10. The Ohio State University Comprehensive Cancer Center, Columbus, OH;

11. Princess Margaret Hospital Cancer Center, Toronto, ON, Canada;

12. Nephro-Urology Hospital Organization, Uddevalla, Sweden;

13. Roswell Park Cancer Institute, Buffalo, NY;

14. University of Florence, Florence, Italy;

15. New York Blood Center, New York, NY; and

16. Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo Foundation, Pavia, Italy

Abstract

Key Points A high survival rate was seen in primary or secondary MF patients transplanted from matched related donors using the FluMel regimen. FluMel plus ATG in HSCT from unrelated donors for MF patients is associated with an increased risk of graft failure.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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