Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells-Reference-Cited by-同舟云学术

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

Published:2013-05-09 Issue:19 Volume:121 Page:3997-4006
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

van Balkom Bas W. M.¹,de Jong Olivier G.¹,Smits Michiel²,Brummelman Jolanda¹,den Ouden Krista¹,de Bree Petra M.¹,van Eijndhoven Monique A. J.³,Pegtel D. Michiel³,Stoorvogel Willem⁴,Würdinger Thomas²⁵,Verhaar Marianne C.¹

Affiliation:

1. Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands;

2. Neuro-oncology Research Group, Department of Neurosurgery, and

3. Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands;

4. Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; and

5. Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA

Abstract

Key Points Endothelial cells secrete exosomes containing miR-214, which suppress senescence and stimulates an angiogenic program in target cells. Exosomal miR-214 regulates ataxia telangiectasia mutated expression in recipient endothelial cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/19/3997/1218641/3997.pdf

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