Correlates of T-cell–mediated viral control and phenotype of CD8+ T cells in HIV-2, a naturally contained human retroviral infection-Reference-Cited by-同舟云学术

Correlates of T-cell–mediated viral control and phenotype of CD8+ T cells in HIV-2, a naturally contained human retroviral infection

Published:2013-05-23 Issue:21 Volume:121 Page:4330-4339
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

de Silva Thushan I.¹²³,Peng Yanchun⁴,Leligdowicz Aleksandra¹²,Zaidi Irfan¹,Li Lucy¹,Griffin Harry²,Blais Marie-Eve²,Vincent Tim¹⁵,Saraiva Mavinga¹⁵,Yindom Louis-Marie²,van Tienen Carla¹,Easterbrook Philippa⁶,Jaye Assan¹,Whittle Hilton¹⁷,Dong Tao⁴,Rowland-Jones Sarah L.²

Affiliation:

1. Medical Research Council (United Kingdom) Laboratories The Gambia, Fajara, The Gambia, West Africa;

2. Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom;

3. Academic Unit of Immunology and Infectious Diseases, Department of Infection and Immunity, The University of Sheffield Medical School, Sheffield, United Kingdom;

4. Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom;

5. Projecto de Saúde de Bandim/Indepth Network, Bissau City, Guinea-Bissau;

6. Department of Infectious Diseases, Nelson Mandela School of Medicine, University of KwaZulu Natal, Berea, South Africa; and

7. Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

Abstract

Key PointsHIV-2 viral control is associated with a polyfunctional Gag-specific CD8+ T-cell response but not with perforin upregulation. Our findings provide insight into cellular immune responses associated with a naturally contained human retroviral infection.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/21/4330/1365993/4330.pdf

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