Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia-Reference-Cited by-同舟云学术

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

Published:2013-05-30 Issue:22 Volume:121 Page:4541-4550
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rajala Hanna L. M.¹,Eldfors Samuli²,Kuusanmäki Heikki²,van Adrichem Arjan J.²,Olson Thomas³,Lagström Sonja²,Andersson Emma I.¹,Jerez Andres⁴,Clemente Michael J.⁴,Yan Yiyi⁵,Zhang Dan³,Awwad Andy³,Ellonen Pekka²,Kallioniemi Olli²,Wennerberg Krister²,Porkka Kimmo¹,Maciejewski Jaroslaw P.⁴,Loughran Thomas P.³,Heckman Caroline²,Mustjoki Satu¹

Affiliation:

1. Hematology Research Unit Helsinki, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland;

2. Institute for Molecular Medicine Finland, Helsinki, Finland;

3. Penn State Hershey Cancer Institute, Pennsylvania State College of Medicine, Hershey, PA;

4. The Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH; and

5. York Hospital, Department of Medicine, York, PA

Abstract

Key Points Somatic mutations were discovered for the first time in the SH2 domain of the STAT5b gene in LGL leukemia. The mutations are activating and lead to increased phosphorylation and transcriptional activity of STAT5b.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/22/4541/1366610/4541.pdf

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