cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2-Reference-Cited by-同舟云学术

cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2

Published:2013-08-08 Issue:6 Volume:122 Page:1042-1051
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Brandherm Ines¹,Disse Jennifer²,Zeuschner Dagmar³,Gerke Volker¹

Affiliation:

1. Institute of Medical Biochemistry, Centre for Molecular Biology of Inflammation, University of Muenster, Muenster, Germany;

2. Biopharmaceutical Research Unit, Novo Nordisk A/S, Maløv, Denmark; and

3. Max Planck Institute for Molecular Biomedicine, Muenster, Germany

Abstract

Key Points A calcineurin-like phosphatase dephosphorylates annexin A2 in the course of cAMP-induced Weibel-Palade body exocytosis. Dephosphorylation at serine 11 of annexin A2 triggers complex formation with S100A10 that is required for von Willebrand factor secretion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/6/1042/1375826/1042.pdf

Reference42 articles.

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2. The Weibel-Palade body: the storage granule for von Willebrand factor and P-selectin.;Wagner;Thromb Haemost,1993

3. New cytoplasmic components in arterial endothelia.;Weibel;J Cell Biol,1964

4. Regulated secretion in endothelial cells: biology and clinical implications.;Datta;Thromb Haemost,2001

5. Biogenesis and exocytosis of Weibel-Palade bodies.;van Mourik;Histochem Cell Biol,2002

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