Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex-Reference-Cited by-同舟云学术

Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex

Published:2013-06-06 Issue:23 Volume:121 Page:4729-4739
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wise Jillian F.¹²,Berkova Zuzana¹,Mathur Rohit¹,Zhu Haifeng¹,Braun Frank K.¹,Tao Rong-Hua¹,Sabichi Anita L.³,Ao Xue¹,Maeng Hoyoung¹,Samaniego Felipe¹⁴

Affiliation:

1. Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX;

2. The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas MD Anderson Cancer Center, Houston, TX;

3. Section of Hematology/Oncology, Baylor College of Medicine, Houston, TX; and

4. Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX

Abstract

Key Points B-cell lymphomas with surface nucleolin-Fas complexes are resistant to Fas-mediated apoptosis through decreased ligand binding. Expression of nucleolin protects mice from a lethal agonistic Fas challenge, whereas a non-Fas binding nucleolin mutant does not.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/23/4729/1365885/4729.pdf

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