Endothelial RAF1/ERK activation regulates arterial morphogenesis-Reference-Cited by-同舟云学术

Endothelial RAF1/ERK activation regulates arterial morphogenesis

Published:2013-05-09 Issue:19 Volume:121 Page:3988-3996
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Deng Yong¹,Larrivée Bruno¹,Zhuang Zhen W.¹,Atri Deepak¹,Moraes Filipa¹,Prahst Claudia¹,Eichmann Anne¹²,Simons Michael¹³

Affiliation:

1. Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT;

2. Center for Interdisciplinary Research in Biology, Collège de France, Paris, France; and

3. Department of Cell Biology, Yale University School of Medicine, New Haven, CT

Abstract

Key Points RAF1 Ser259 phosphorylation is a critical regulator step controlling arterial morphogenesis and arterial-venous patterning. ERK activation controls DLL4/Notch signaling and semaphorin 6A–mediated endothelial cell repulsion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/19/3988/1218692/3988.pdf

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4. Dll4, a novel Notch ligand expressed in arterial endothelium.;Shutter;Genes Dev,2000

5. DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries.;Sörensen;Blood,2009

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