Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus-Reference-Cited by-同舟云学术

Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus

Published:2013-10-03 Issue:14 Volume:122 Page:2358-2368
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tinsley Kevin W.¹,Hong Changwan¹,Luckey Megan A.¹,Park Joo-Young¹,Kim Grace Y.¹,Yoon Hee-won¹,Keller Hilary R.¹,Sacks Andrew J.¹,Feigenbaum Lionel²,Park Jung-Hyun¹

Affiliation:

1. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; and

2. Science Applications International Corporation–Frederick, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD

Abstract

Key Points Ikaros suppresses thymocyte proliferation but induces antiapoptotic molecule expression upon TCR-induced positive selection. Ikaros function is required to prevent clonal expansion and to maintain a random TCR repertoire during thymocyte differentiation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/14/2358/1371054/2358.pdf

Reference49 articles.

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2. Regulation of thymocyte development: only the meek survive.;Love;Curr Opin Immunol,2003

3. Positive and negative selection of T cells.;Starr;Annu Rev Immunol,2003

4. Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor.;Aifantis;Immunol Rev,2006

5. Kinetics of mature T-cell development in the thymus.;Egerton;Proc Natl Acad Sci USA,1990

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