Incidence and prognostic relevance of genetic variations in T-cell lymphoblastic lymphoma in childhood and adolescence

Author:

Bonn Bettina R.1,Rohde Marius1,Zimmermann Martin1,Krieger David12,Oschlies Ilske3,Niggli Felix4,Wrobel Grazyna5,Attarbaschi Andishe6,Escherich Gabriele7,Klapper Wolfram3,Reiter Alfred1,Burkhardt Birgit18

Affiliation:

1. Non-Hodgkin Lymphoma Berlin-Frankfurt-Münster Group Study Center and Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany;

2. Department of Internal Medicine V, Justus Liebig University, Giessen, Germany;

3. Department of Pathology, Hematopathology Section and Lymph Node Registry, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany;

4. Department of Pediatric Hematology and Oncology, Children’s University Hospital, Zurich, Switzerland;

5. Department of Bone Marrow Transplantation and Childhood Oncology and Hematology, Medical University of Wroclaw, Wroclaw, Poland;

6. Department of Pediatric Hematology and Oncology, St. Anna Children’s Hospital, Medical University of Vienna, Vienna, Austria;

7. Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; and

8. NHL-BFM Study Center and Department of Pediatric Hematology and Oncology, University Children’s Hospital, Münster, Germany

Abstract

Key PointsConfirms the prognostic effect of NOTCH1 mutations in pediatric T-cell lymphoblastic lymphoma in a large and independent cohort. Provides the scientific basis for using NOTCH1 mutations and chromosome 6q alterations as stratification criterion in patients with T-cell lymphoblastic lymphoma.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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