Trogocytosis of multiple B-cell surface markers by CD22 targeting with epratuzumab-Reference-Cited by-同舟云学术

Trogocytosis of multiple B-cell surface markers by CD22 targeting with epratuzumab

Published:2013-10-24 Issue:17 Volume:122 Page:3020-3029
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rossi Edmund A.¹²,Goldenberg David M.¹²³,Michel Rosana¹,Rossi Diane L.¹,Wallace Daniel J.⁴,Chang Chien-Hsing¹²

Affiliation:

1. Immunomedics, Inc., Morris Plains, NJ;

2. IBC Pharmaceuticals, Inc., Morris Plains, NJ;

3. Garden State Cancer Center, Center for Molecular Medicine and Immunology, Morris Plains, NJ; and

4. Cedars-Sinai Medical Center/David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA

Abstract

Key Points Epratuzumab induces the reduction of multiple B-cell antigen receptor–modulating proteins on the surface of B cells via their trogocytosis to effector cells. Modulation of B cells by trogocytosis of key regulatory proteins may be an important mechanism of immunotherapy of autoimmune disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/17/3020/1369775/3020.pdf

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4. Epratuzumab (humanised anti-CD22 antibody) in primary Sjögren’s syndrome: an open-label phase I/II study.;Steinfeld;Arthritis Res Ther,2006

5. Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus.;Dörner;Arthritis Res Ther,2006

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