Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells-Reference-Cited by-同舟云学术

Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells

Published:2013-04-25 Issue:17 Volume:121 Page:3413-3419
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Walker Brian A.¹,Wardell Christopher P.¹,Johnson David C.¹,Kaiser Martin F.¹,Begum Dil B.¹,Dahir Nasrin B.¹,Ross Fiona M.²,Davies Faith E.³,Gonzalez David¹,Morgan Gareth J.¹

Affiliation:

1. Molecular Haematology, Haemato-Oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom;

2. Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom; and

3. Myeloma Targeted Treatment, Haemato-Oncology Research Unit, Divisions of Molecular Pathology, Cancer Therapeutics and Clinical Sciences, The Institute of Cancer Research, London, United Kingdom

Abstract

Key Points IGH translocations in myeloma can occur through at least 5 mechanisms. t(11;14) and t(14;20) DH-JH rearrangement-mediated translocations occur indicating these appear to occur in a pregerminal center cell.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/17/3413/1364834/3413.pdf

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